Microfluidic‐Assisted Production of Gastro‐Resistant Active‐Targeted Diatomite Nanoparticles for the Local Release of Galunisertib in Metastatic Colorectal Cancer Cells (Adv. Healthcare Mater. 6/2023)

Nanoparticle Drug Delivery The encapsulation of nanoparticles in hydroxypropyl methyl cellulose is key to treat colorectal cancer through oral administration. In article 2202672 by Ilaria Rea, Hélder A. Santos, and co-workers, gelatin-coated diatomite loaded with galunisertib are functionalized an anti-L1-CAM antibody that targets metastatic colon cells. These then encapsulated a gastro-resistant matrix using microfluidics. When the interact targeted cells, coating dissolves released.